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· overview a muscle cramp is a sudden, unexpected tightening of one or more muscles. · polymyalgia rheumatica is an inflammatory condition. · tizanidine acts on the central nervous system (cns) to produce its muscle relaxant effects. · muscle pain that is felt throughout your whole body is most often caused by an infection, such as the flu. · very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-ol-ih-sis). Its actions on the cns may … It causes joint and muscle pain and stiffness, mainly in the … Sometimes called a charley horse, a …