What Happens When Your Brains Memory System Fails Representational Drift Of Hippocampal Neurons Alters Spatial Memory In Mice

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· the hippocampus is thought to mediate episodic memory through the instantiation and reinstatement of context-specific cognitive maps. Recent experiments reveal that neuronal … · nevertheless, the finding of representational drift raises profound questions about how behavior is learned and controlled in neural circuits, and what constitutes a memory of such … · multiday imaging of ca1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases … · representational drift, while seemingly counterintuitive for stable memory, is a sign of a healthy and adaptable brain. · memories of places “drift” in the brain – even when the environment doesn’t change “this result really changes the way i think about long term memory storage,” senior … Within a fixed, familiar environment, hippocampal codes gradually change over timescales of days to weeks-a … · experiments that track hippocampal place cells in mice navigating the same real environment have found significant changes in neural representations over a period of days 1, 2. · synaptic plasticity is widely thought to support memory storage in the brain, but the rules determining impactful synaptic changes in vivo are not known. · even in a controlled world, hippocampal neurons remap daily, which could reshape how we understand memory, aging, and brain flexibility. This dynamic nature allows the brain to integrate new information … · spatial memory in the hippocampus involves dynamic neural patterns that change over days, termed representational drift. The nervous system learns new associations while maintaining memories over long periods, exhibiting a balance between flexibility and stability. · distributed population codes can accommodate representational drift representational drift might appear problematic for long-term encoding of memories and … The hippocampus forms unique neural representations for distinct experiences, supporting the formation of different memories. 1,2,3,4,5,6 hippocampal representations gradually change over … · in a groundbreaking study that challenges longstanding assumptions about neural stability, researchers have meticulously investigated how hippocampal place cells—neurons that … While drift may aid memory updating, excessive drift … · neuroscientists reveal hippocampal “representation drift,” a dynamic re-mapping of spatial memory despite stable environments, observed via two-photon calcium imaging and vr. · abstract hippocampal activity is critical for spatial memory.