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Zofran is used to prevent … View ondansetron information, including dose, uses, side-effects, pregnancy, breast feeding, contra-indications, important safety … Ondansetron, sold under the brand name zofran among others, is a medication used to prevent nausea and vomiting caused by … · find patient medical information for ondansetron (zofran, zofran odt, zuplenz) on webmd including its uses, side effects and … · zofran blocks the actions of chemicals in the body that can trigger nausea and vomiting. · ondansetron works by blocking serotonin from acting on the receptors, and this stops you from feeling sick or being sick …